Novel Nanoprinting for Oral Delivery of Poorly Soluble Drugs
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چکیده
منابع مشابه
Nanoemulsion Formulations for Improved Oral Delivery of Poorly Soluble Drugs
The objective of this study was to develop nanoemulsion formulations for enhancement of oral bioavailability of paclitaxel, a model hydrophobic drug and P-glycoprotein substrate. The oil-in-water (o/w) nanoemulsions were made with pine nut oil as the internal oil phase, egg lecithin as the primary emulsifier, and water as the external phase. Stearylamine and deoxycholic acid were used to impart...
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Nanotechnology has been improving and has a variety of application fields. One of the major application areas of nanotechnology in pharmacy is nanoparticular drug delivery systems. Preparation of drug nanocrystals to improve the solubility of poorly water-soluble drugs for oral delivery is also one of the important applications. Nanocrystal dispersions comprise water, active drug substance and ...
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A major hurdle in pharmaceutical formulation is water insolubility of most of drugs affecting their stability and bioavailability. If the drug is also insoluble in organic medium, it is difficult to deliver it in a sufficiently bioavailable form and hence it is a great challenge to formulation researchers to overcome such difficulty. Although some approaches are available for enhancing th...
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Solubility of drug plays critical role in achieving the optimum therapeutic levels of the drug in blood and thus bioavailability. There are many drugs of various therapeutic categories fall in BCS class II and IV as they lack solubility. For all these drugs dissolution is the big hurdle for the absorption process. Present review’s focus is mainly on novel techniques of improving the solubility ...
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The oral bioavailability of BCS (biopharmaceutics classification system) class II drugs with poor solubility and reasonable permeability is limited by the drug dissolution step from drug products. Though prodrug approach is an exciting way of improving the oral bioavailability, it requires extensive studies to establish the safety profile of prodrugs in humans. In view of the increasing market ...
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ژورنال
عنوان ژورنال: Methodist DeBakey Cardiovascular Journal
سال: 2016
ISSN: 1947-6094
DOI: 10.14797/mdcj-12-3-157